חומר רקע
¶§´µ¸
¸£§¬£ª¸£§ ¦¶¦¯i¸§¬£ª§¢¸§¸££·¢¢¢®¡¯¢
«ª£°£ª¶·§§£²¶£§¢¶µ¥¬¢£¬§¬ª£«£¡§µª
trr{¶¬´¡uotn°d·¸£ª¯©¤d¦o£d¦«§¬§¢©¶°®¢®¡¯¢
«§ª·£¶§¢§¬¡µ¢¸§
§£ §¢¢¸¡°£¥£¡«£¯¶²¸£µ°
ª¶·§§£²¶£§¢¶µ¥¬¢´¬¸©¶°¢ª
±¢¯°³
«¤i¡¢¬£¤
§««ª¡¢¡¡ ª¡
¥«¬
nllu±§¯oinh«^²³¥ª¤^¡i^¡¦¢§¢¤±«©©ª
¦¢¥²±¢¢§°³¢
¢¢³« ¦ª±³°«
¥±²¢¢±¢±° §¯§³¤±«¥
¦¢«§¥³¢¥±²¢³¢§¥¢§°
nlmlª±§k«^²³±¦¢¥²±¢
©
«^²³h¦¢«§¥³¢¥±²¢³¢§¥¢§°
¢³¢§¢¡ªv°±ªh¯¢«
±¥¡¢h¨§¢±±^vª¥
¦¢©¢¢©«¨¤³
q
§°
s
©ª³¢©¤³
mo
©ª±¢¯°³
nu
¢¢³« ±¢¯°³
s
§°
i³¢§¥¨¢³¢³²©ª§³¯¥§³©°ª§
¥±²¢¢±¢±° §¨§¢§¥¦¢°¥³¢§¥³¢¡±¡ª
¦¥«
¢§°³¢nllu±§¯oinh«^²³¥ª¤^¡^¡¦¢§¢¤±«©²
¦¢¥²±¢
³¢§¥ ¢§° §¢¢°³² ³¢§¥¨¢ ©ª ¥² ±¢¯°³ ¬±¯§ jm
j¥^©²©¥«¦¢©¢³¦¤ª§hnllu±§¯¦¢«§¥³¢¥±²¢
£§³©¨²¦¢¤±¥«§¥¥©¤£³§¢§°¢¢¥«©±©ª
¥²³«³°«¤±«©©ªj±«§³¯±¢±¢±° §
¦«¡§¥«²h¥±²¢¢±¢±° §¯§³¤±«¥¢¢³«
¢±° §²¯§«jdnlluinllre¦¢¢³©²¤£²§¢§°
¦¢¥±²¢¦¢±° ¥±²§©¢¯§¨§¢§³³§®±¥ª¢±
j¦¥²¥¢¯©¡¥§³²§§¥
j¢²¢©§±h³±¯h¢¥©h³¢±³¯±§¦¢©«§³³²©ª jn
¢±¢±° §¥²¨§¢§¢©©©§±«§¢§¯«¦§ ¥¤
j¯±
¦¢¡¢²¥²³©¢§§³ ¥¤§©²¥±²¢²©§¥©ª¢©¢§ jo
v¢±¢±° §¤¢§³¥¦¢«©
±° §£§³¥³±¯§³¢³¤¥§§³¢ §²¢³©¢§§³ ¥¤ j
j¢±¢
±²§³±©³ ¢§¨±°³§¢¢°d¢©§±¥§e³©¢§§³ ¥¤ j
j¥¢±¢±° §¥³¢«¢¢h«§³¤§³³©±°
h¥²¦¢¢¤±§¦¢¥ ¢³¢©¢¥°±° §£±«§³©¢§§³ ¥¤¥ j
j¥²§§¢¢¥«³©²³±¯£§³©²
¦¢§¤ª §© ¥ ³©¢§ ¢±¢ ±° § ¥² ¨§¢§ ¢°¢ jp
vd^±¥²±¥e
¢±¢ ±° § ¨§¢§ ¦¢°¥ ³¢¡±¡ª v³¢§¥¨¢ ©ª§ ±¢¯°³
t
±¥±¢¥¢§mol³¢±³¯±de
±¥±¢¥¢§njn¢¥©de
i ³¢±¢¯ ¨±°§ ±¥ ±¢¥¢§ njn ¥² ¦¤ª ¢¥©¥ h¬ª©e
dWelcome Trust
±¥¨¢¥¢§tqt¢²de
£h¢±¢±° §¦¢¥¬ª¤¢§¤ª¨¤¦³«¢°²§³±¯¢©§±
j¨³«°²³°¢§² ¥±³¢²°
¨§¢¥h¦¢¤¥±²¢¢±¢±° §³¥¥¤³¢³©²«°² jq
h±§¥¤j±¥¨¢¥¢§nql«nll¤¢OECD¢©³©¥«ªª³
© § qla§ ³ ¢ «°² h¢ª¥¤ ¥¥ ²
j£¢¢³²¥¥±²¢³©¢§³²¨¢¥²OECD³¯±
¢±° §¯§³¤±«¥¢¢³«¥²³«³°«h¦¤¢ª¥jr
¨¢©ª³©°ª§¥£²§¢§°¦«¡§¥«²¥±²¢¢±
³©¢§²¢±¢¤¢³¢±°¢«©³¯¥§i²©§¢¢°³²³¢§¥
¢±° §¥² ³¢¥§¢°¥³¢± ³¢¥«¥°³¥±²¢
©²¢¤i² ¢±° §¦ ³¤¢§³¥³ ¢§¨±°¦¢°³¢±
j³ ³§¦¥«³¯±
©ª³¢©¤³
mm
©ª³¢©¤³
v³¢§¥¨¢³¢³²©ª
±° §¨§¢§¥¦¢°¥³¢§¥³¢¡±¡ª
¦¥«¥±²¢¢±¢
nllu±§¯oinh«^²³¥ª¤^¡i^¡¢²¢§ ¢«¢±¦¢§¢
¦¢«§¥³¢¥±²¢³¢§¥¢§°³¢
Wednesday, December 2nd 2009
09.00i09.30 Opening Remarks and Greetings
Prof. Menahem Yaari, President of the Israel Academy Sciences
and Humanities (IASH)
MK Yakov Litzman (Israel), Deputy Minister of Health
MK Meir Sheetrit (Israel), Chairperson, Science and Technology
Committee, Knesset
Prof. Manuel Trajtenberg, Chairman of Planning
& Budgeting Committee, Council of Higher Education
Prof. Ruth Arnon, Vice-President IASH and Chairperson, The
Committee for the Assessment of the State of Biomedical Research
in Israel
09.30i11.00 The National Policy for the Support and Funding
of Biomedical Research; Basic, Clinical and Translational
Chair: Prof. Michael Sela, Weizmann Institute of Science, AISH
Member
Prof. H. Fineberg, (USA) President of the Institute of Medicine of
the National Academies
Prof. Willam Paul, (USA) National Institutes of Health (NIH),
NIAID
Prof. Christopher Kennard, (UK) Oxford University and Medical
Research Council
¢±¢ ±° § ¨§¢§ ¦¢°¥ ³¢¡±¡ª v³¢§¥¨¢ ©ª§ ±¢¯°³
mn
11.30i13.00 The National Policy for the Support and Funding
of Biomedical Research (continued)
Chair: Prof. Raphael Mechoulam, Hebrew University, AISH
Member.
Prof. Jean-Francois Bach, (France) Permanent Secretary, Academie
des Sciences, former Director Institute for Immunology, INSERM
Prof. Reinard Kurth, (Germany) Chairman of Ernst Schering
Foundation, Former President of the Robert Koch Institute and
Paul Ehrlich Institute
Prof. Olle Stendahl, (Sweden) Linkoping University, Former
Secretary General of the Swedish Medical Research Council
14.00i15.30 Biomedical R & D in Israel
Chair: Prof. Uri Seligsohn, Sheba Medical Center and TA
University, AISH Member
Policy, Support and Funding of R&D in Israel - Overview
Mr. Yigal Erlich, Deputy Chair of The National Council for R&D
Findings and Recommendations of the Committee for the
Assessment of the State of Biomedical Research in Israel
Prof. Ruth Arnon, Vice-President of the Israel Academy of
Sciences and Humanities and Chairperson of the Committee
The State of Clinical Research in Israel
Prof. Gabi Barabash, Tel Aviv Medical Center and TA University
Biomedical Funding by the Israel Science Foundation (ISF)
Prof. Benny Geiger, Weizmann Institute; Head of the Division of
Life Sciences and Biomedical Research, ISF
16.00i17.00 Summary and Discussion
§°
mo
Thursday, December 3rd, 2009
09.00i10.30 National Support of Biomedical Research - Expert
panel all presenters-Israeli and guests
Chair: Prof. Alex Keynan, Israel Academy of Sciences and
Humanities
11.00i12.30 Expert Panel (continued)
12.30i13.00 Summary and Conclusion
Prof. Ruth Arnon
The Workshop was made possible by the generous support of the
Charles H. Revson Foundation, the Yad Hanadiv Foundation, and
by the Eli and Marilyn Goldfarb Grant.
©ª±¢¯°³
ms
©ª±¢¯°³
«°±
¦¢±° ¥³±²§©¢¦¢¤¥±²¢¢±¢±° §³¤±«§¢¤² ³
³¢§¥¢§°³«¢©¦¥²¥¢¯©¡¥§³²§§¥¦¢¥±²¢
¢±¢±° §¯§³¤±«¥³ ¢§«¦¢°¥¦¢«§¥³¢¥±²¢
³±c±§«²±²h«j°§«¥²©³¨ ¥¢¤¥±²¢
³²¢h«¥«¢¢ª²h¦¢¢§¥¨¢¦¢ §§¥²¦¢³¯²¥²h¨©±
jnllt±§©¦¥²¢ª
£¢²§¥²°¢hd³¢±³¯±e¨ª±^c¯¨±°¨§¢§¤±«©²h©ª
¢±¢±° §³¤±«§³²³«¯§¢ ±¥«³«³
¦¢¥¢°§¦¢¥²¥¥h²¨§¢§³§±¨§¢§¢©©©§¥«h³¢¥±²¢
j¥^
³¢¥±²¢³¢§¥¢§° ¢²© h¢±«¢ ¦ ©§ c± ³ ©ª ³
h³¢±¡²±¢§³ª©¤± w³¢±±²¨ªh¨§¯¢¥°«¢³ª©¤± w¦¢«§¥
²¢h±©¡¤±¡¥©§c±w³ª©¤¥²¢¥©¤¡«§³«²±²¢
³«±j¥¤²¥¯«§¥²d³^³e¯°³¨©¤³¥«²±
¢±¢±° §±¢²¥°§«¦³¢ §³¦¥¤²¢¦¢±
¢³¯ ³²¥²²e ¨©± ³« ¥² ³¢±°¢« ¯¥§ ³ ¯§ j¥±²¢
³§°i¥²§¥ ³³¢±¡²³ª©¤± ¢¯hd¤§³¥^ §¦¢ §§
d³¢±³¯±NIH³§e^³¢±¥¦¢¢¥±²¢¦¢¢§¥¦¢©¤§^
j©¢§¢±¢±° §³° ¥¢¤
§«§^¢¤±§h¥±²¢³¥²§§«§±²h®¢°²±¥¢©c±
¥²³©°ª§³¢¥^¨¤³§²^¢±¢±° §¨§¢§³¢² ¥
¥§^³¥«h^¢¥©¤¡«§¢²©¥³¢±²§¨¢«¥¨©±
j¨§¢§³¥¢¥³ª©¥¢¤h^¥²§§¥²³¡¥ ³¥°³¢¤§ª
¢±¢ ±° § ¨§¢§ ¦¢°¥ ³¢¡±¡ª v³¢§¥¨¢ ©ª§ ±¢¯°³
mt
¥^ §¦¢ ±¢±
±¥ ¢°¢±§ ¨¤§ ¢²© hd³¢± ³¯±e ±©¢¢ ¢± c±
¥§³±¢°ª³¢§¥¨¢³²³±ª³ ³hdNASkIOMe
±³¢¢¯§³¢±³¯±¢¤±§j¢±¢±° §¨§¢§¥¢°¢±§
j³¢±¦ ³¥¦¢±²°¦¢²© ³¢±° §¥«±¥±¢¥¢§mol§
v¨¥¥¤h¢³±°§¢¥h¨§¢§ ¥¢
±¥±¢¥¢§spjt
¢¢²«³
±¥±¢¥¢§osjs
°¢¡¯§±
±¥±¢¥¢§nsjq
¢¥©¤¡¢
±¥±¢¥¢§ujr
±
±¥±¢¥¢§otjr
¢¥±¥²§§
±¥±¢¥¢§nujo
dNIHe³¢±¥¦¢¢§¥¦¢©¤§
±¥±¢¥¢§ujo
±
±¥±¢¥¢§msjm
¦¢± ³±°§
±¥±¢¥¢§mljp
³¢ª§³¢¡¢ª±¢©³©±°
±¥±¢¥¢§rjs
± h³§±³h³¢±³¯±³©¢§
³¢±° §¦¢¤©¬ª¤¢§¤ª¦¢«¢°²§¦¢±§¥¤¢°¢±§¥§
±° §¢¤¦¢¢²«³¨§«¢§¨§¢§¥²¢±°¥ j³¢±¦ ³
¨¢¤±§¥²§§¥²³§±³j³ ³ «¢°²§¢¢ª¢ª
¯¢ j^§³¥ ²©¥ ² ³ ¦¢¥§±©§ ±²¤ ¦ ¢§
¢§¯¥¨«©§¤³¢±³¯±¥¢³«§²§² ¢±¢±° §²
¦¢©²h²«§¥j±³¢¡³¢±¦¢°¥¨³¢¥¤¥¤
£³§i±¢§ ³ ³¢±° §¥²¢ª ¢¦°¥ §¯nlltimutn
±¥¨¢¥¢±¡n§±³¢¨²e³¢±³¯±³¢±¦ ³³¢¥«¥¥¤
³¢¢ª¥¤§ora²¥«¦¢¢©¤«¦¢±°ª§jqjqa¥ojla§id·]µ©²
opa«²hmla«sa¥i¥¢¬¢ª¢ ²¦¢©¢¢©«§³¢±³¯±
j¦ ³«°²¥²±³¢³³§±¬¦¢¯±¢©¢§³¢¢ª¥¤§
¯°§dª±©°e°° §¬d¥±²¢§® e³ ³§³©¢§³¢±§
³¢ ±° §¥ ³¢«¢¢ h³±© ³¢©¤ª¥ ³±¢²¢ ¥²§§ ¢ª¤ ³
©ª±¢¯°³
mu
h«¢²¥ °¥ ©¢¯°³§¬¢¤²¢¥² jdc¤NIHhNSFe
¢³±¢²¦¢°ª§¢³¥²§§±²§°¥ §¥²h¥ ¥¨³¢©²¤
¥¥¤¨§¢§³¥¥±³¢±±³©«¢¢¢¥¢§²¢j³¢±
±¢¯e¦²§¨«§¥«¢¯¥±³¢¦¢©¤©³¡¥ ¢¥°§²¨¢¤§
¦±¥¥¤¢v³©±ª ¦±¥¦¥j¦¢¡¥²¦²¦¢¯±d¦¢±
¢± ¨§¢§ ³¥¤ §¥e ¨§¢§ ¥² ³¢¯¢¥ ³©³²§ ³§±¥
h«¢²¥ª±¡©¢³¯°³¢¡¢¥³¯°¥²³±²¥hd¤§© ¢§¯
¥³©±ª ¦¥j³¥¥¤³¢§¥¢¡±¡ª±«¢¥³¢¡¢¥³¯°¥
¨§¨§¢§¥² ±¬°¢v¥§¥²³©±³¢©¤¦¢¥°²¦©¢
³§¢ ¢« ¤±« £¢¥³ ³¢°² h³¢±¢¯ ¤¢§³ h³±°§
j³¢«§
©¢§¬¦¢±¢¤§©©¢^h¨§¢§£±³±²³¢¤±§¦¤¢ª±©¢¢
¥²° ³¢³²³¥¥ ¢¥¯§³¢±¢¢¢²«³³¢¢© ¢¥¯²³
²°©j ¯©¥c¦¢± ¥²¦¥«¤±¥c±²¢j¢ª¢ª±° §
j^³ ¢§³¢± ¦¢²©³¢©¢§¢¯«§
NIHkNIAID¢¥©§¢¥«§§d³¢±³¯±e¥¦¢¥¢c±
hdNIHe³¢±³¯±³¢±¥¦¢¢§¥³ª§¥²¨§¢§©§¨
j³¢±³¯±¢±¢±° §¥²¢±°¢««¢©§ ¤°ª¥¥¦²
¥¤h¦¢©¤§¦¢±²«§¦¢¤±§³¢±³¯±³¢±¥¦¢¢§¥³ª§
¥¦¢¢¯°³j±©¢¢¥«¨§§§¢§¯«¨ª±©°¥©¦§
±° §¥³±¢²¢¦¢¢¯°³§°¥ ³©¤¥³¢§¥³¢ §¦¢°²§
d¦¢¢±¦¢©¥¤³¦¢¥°§²ISFNSF§¤¥²e¢±¢
¥©§³±§¢ª£³j³¢¢«±ª¢¥«¨§¢§³³¯°¥
Commone³¢¥¥¤¨±°³±¢²¢¥¢«§³¢¥¥¤©¤¢ ©¨³©NIH
¥§°²hd¥¥¤NIH¢¯°³£³§mjsa°±e³¢ª ¢©¡°hdFund
j±¤§
¦¢ e¦¢±° §¨§¢§¥«¢§NIH¥²±° §¢¯°³§¦¢ ¦¢«²³
¦¢¥ ¢³ h±¥ ±ª ¢³ h³¡¢ª±¢© dnla§ ¨¡° ¬°¢
¢°©«§¦¦¢°©«§±j³¢±³¯±¢±±° §¥³ª§¦¢¢±° §
¨§¢§¥±¥nqlhlll«h¦¢©²²§ «²¥²eROmª§¦¢¢¡±±° §
£ jd³¢°« ³¢¥« ¢ª¢¤¥ sla « ¥² ³ª³ ³±¢²¢ ³¢¥«
¢±¢ ±° § ¨§¢§ ¦¢°¥ ³¢¡±¡ª v³¢§¥¨¢ ©ª§ ±¢¯°³
nl
¦¢¥¦¢³¯¦¢²±©¦²h¢©¢¥°±° §¦ ³±°¢«h¦¢§ ³²¢
¦¢¢³«§²§ ¦¢°©«§ rl¤¨§§§NIH ¦¢¤ j¦¢«¯§ ¢¯ h¦¢©§
u¤¥²«¯§§¢©¢¥°dtranslationisciencee¢§±³±° §¦ ³
h¨¡±ª±° ¥¦¢§°³§¦¢¤±§¦¢¥«¥«¬ª©j ±¥¨¢¥¢§
j«³¢§¯«³©¢ª ±° ¥³²±hª¢¢¦¢¢©¢¥°¦¢¢ª¢©¥±° §³¯°
¥¤h¨±£³«¯³§±° §£§³NIH¢¯°³§mla°±¦©§
¦¢¢²±¦¢±° mhnlli±¥±¢¥¢§o¤i¤§¦¤ª±§³
±° §¤±§¥±©¥¤¤³¦¢²«NIH ¥² Bethesda ª§°
j¦¥«±³¢¥¢±¢
§¥e¨¤¢ª±¢³«£¢§¢±° §¢«¥¦¢ ¢§¦¢©©©§¦¦¢§¢¢°
¦¢ª¤§NIH¢°©«§j¦¢±¢«¯¦¢±° ³«¥d¦¢¢¯¥ ¦¢±° §¥¦¢°©«§
¦¢±° ¥²¦¢³±¤²§³¥¥¤h±° §¥²³¥§³¢¥«³
j¢¡¡¥° ¢¡¢ª±¢© ¨§¢§ ¦¢¥°§ ¢ ³¥§ ¥§¥² h¦¢¢²±
³«¯³±¢°ª¥²§²§¨§°±³¦¯§¯¥³«ª©§NIH¬ª¥
³«¯³²°¬°¢³¥³«¯§¢¥«¥¡§ª§«³³¢ ¥
²«§§¨§°±±¯°³nllu³©²j¥¦¢§«mn¥±° §
±¯°¨§°±³¢h¥¦¢² ²¥²¥¡¥ ³¥°«§«
j³ ¦«°±³±³§«¯¥²² §²j¦¢±° ¥£±«¥«
³«¯§¥©§³¢¥¥¤¢©©¢³§¢©² ¢©¢¥°±° §^¢¤¨«¡¬¥
¥¢j³§°³§³¢³²³¢¡°£±¯²¢j¥¦¢¢¥¡°¢±±° §¢°©«§
±©¥¤¤°¢ª§©©¢©²¥±¥nqlhlll¥²¢ ¢°©«§³¢±³¯±
h³§¢²±§¡¥ ¨³² ³¢¥©¤¡j¦ ³³¢³± ³«§¥¢©¥
³¢¥¢¤j^¢ ¢¥±¥¨¢¥¢§¢¯ ¥«DNA¢¯±§¥²±¦¥
¥¤³¨² ¢¥²¢h¦¢¢¥²±²¢¥¥±° §¦¢¢¤±§¦¢§±
^¢§¥¨¢ ¤^³¢¥¥¤¢¥±²¢¢¤¨¢§§¥j¥¥¦¢©³©¦¢©³
³¦«j¥³§³¯±¨¢§^±³¢¥¢«¢^¢²¢³§²±³
±° §³¤¢±«¥¨§¦¢¥±²¢¦¢±¥¯°§¨¢²«¢¤¨¢¢¯§
j¥±²¢¢©¢¥°±° §³§³¤«§
¢MRC±ª°³¡¢ª±¢©§d¢©¡¢±e±©°±¡ª¢±¤c±
slp¢nlltklu¦¢©²dMRCe¢±±° §¥³¢¡¢±¯«§¢¯°³¢¤
¢§¢©¨§¢§¥²°¦¤ª§³¢¯ §¤jd±¥±¢¥¢§mjm¤e¡^²¢¥¨¢¥¢§
©ª±¢¯°³
nm
nu¢±±° §¥³¢¡¢±¯«§¥²¦¢©¤§²¥²¦¢±° §¥²
oholl©§¢§¢¢©²³¢¯ §j¦¢«phlll§±³¢ ¢¦¢°¢ª«§h³¢ ¢
³¢©¤³³±²¤¨§¢§¥¯°±¥¨¢¥¢§uo¤j³¢©¯¢ ±° §³¥§
^¨¢¢¥ ¨±°«^ ³¥ ¢± ±° §¥ ³¢¡¢± ¯«§ j±¢¢±° ³¢¥
³±«§ ©¢ £ ¨§¢§ ³ ³°ª§ ¥²§§ ¢¤ «° hdHaldanee
j³¡¥ ³¥°
¡^²¢¥¨¢¥¢§tll£ªi¬ª©¨§¢§°¢©«¥©¢¡¢±³¢±±²§
NHS iNationale¦¢¢§¥³¢±¢³±¢²¥id±¥±¢¥¢§mjo¤e
²§¢²¥«¢¤¦¦¢¥ ¢³ ³¢±° §³±¡§¥dHealth Service
±²§¥²³¢©¤³±«nllr³©²j¦¢¥ ¥¢¡¥¨§¢§§±¤¢©°¥
³¢± ¦ ³ ±° §¥ ¢§¥ ¨¤§ i ² ¬¥ ¢¡¢± ³¢±
³¢¢¯°³ dNIHR iNational Institute of Health Researche
h¦¢¥² §¢¯°³jdMRCe¢±±° §¥³¢¡¢±¯«§¦«
³±¢²¢ «¢§ hd±¥ ±¢¥¢§ njos¤e ¡^²¢¥ ±¢¥¢§ mjpt ¦¢¤²
¢dnllre«²±dCooksie Reporte¢ª°° j±¯±²§§
OSCHR ie³¢±¦ ³±° §¥¢¡±¡ª¦¢³¥±²§³§°¢¢¥
³¤±§hdOffice of Strategic Coordination of Health Research
±¯¢¢¥¢¤³¢±¦ ³±° §¦¢©¢¢©«§¥²§§¢±²§¨¢¦¢³
³©±°¢¢²«³¢¦«¦¢³¦ ³
F³¢±° §³¢§¥¢¡±¡ª¦°¥
±²§¥²¥©§«¦¢± ¥¥¦¢¢¥©§§¦¢±e¦¢§¢³§³©©
jd¦¢³
«nllu¦¢©²¥¢±±° §¥³¢¡¢±¯«§¥²³¢¡±¡ª³¢©¤³
±° §e^Research Changes Lives^³±³¤³ ³©± ¥§ª±nlmp
jd£¢¢ ³©²§
¢±° § ¦ ³ ¥¢§ ¬ ¢ ¢± ±° §¥ ³¢¡¢± ¯«§ h¥¥¤¤
k¢§²¢¢±° §¥¢§³¢±¦ ³±° §¥¢§¥¨¤§h²²¢k¢¥¢
¨±° ¦ ¥¢«§ ¢ jIII ¥² II ¥² ¦¢¢©¢¥° ¦¢¢ª¢© ¥¥¤ h¢§±³
d±¥¨¢¥¢§rpe¡^²¢¥¨¢¥¢§pl¤¥²£ª³§¯§¯§³¢¤±§³¢¡±¡ª
°°¢±¯±± ²¥³©¤§³§¢³±ª±¢§³k±¢°ª³±¡§¥
jd¦¢±°±§¢¦¢¥§¥²³§¢§¥e¢§±³±° §¦¢¢±° §
¢±¢ ±° § ¨§¢§ ¦¢°¥ ³¢¡±¡ª v³¢§¥¨¢ ©ª§ ±¢¯°³
nn
Theh¥³¢¡±³©©¨±°³¥«²£¤³¢ ¢¢¢©¡¢±¬ª¥
¯«§¥²¥§§±¢±¢±° §³©§§§hWellcome Trust
¨±°jd±¥±¢¥¢§mjmn¦²h¡^²¢¥¨¢¥¢§slne¢±±° §¥³¢¡¢±
¤±§§¥e±° §¦¢°¥¦¢² ³¢³²³¢¤±§³±²¤¦³©§§§
¨§¢§¬©¢§¥¥²¨§¢§§°¥ ²§³²¢jdSanger Centeri±©ª
³©¢¯§£±i¢©¡¢±¢ ±¦¢¥¢§±° §¢©¤§±²«¥¦³¢³¥²§§
j³¢³¥²§§³±«§¢«¥
³¢³±¯¢§°¥²¢²±±¢¤§hd³±¯e£ª©±¨cc±
±° §¢§ ³¦¢±° ¥¤¡«§¤²£¤³ ¢§³±¯²¨¢¢¯h¦¢«§¥
±° §¥¢§¥¤±§eCNRS¦i©¢§¢ª¢ª¢±¢¢¥¢
d±³¢±¢§ ³±° §¥¢§¥¨¤§eISERM¦hd¢«§
¢§²±¨¥²§§¢¢¥«¦¢°ª«§id«INRAhCEAe¦¢± ¦¢
¢³°ª«³¨ ¡¢joq¥¢§¥ h¦°§¥¢¦¢³±²§³«¢°§¦¢©©
¢¥¥¤¢¦¥d¢ª¥§¨¢e³¢³±¢¯¢««¥¥¤¢¤²
¦ISERMCNRSj^¦¢³§¦¢©«³¦¥^±²¢i¨¢°¥¦
hCNRS³§«¥¦¥j¦¢¤±§§ ¥¤¦¢©«§ohlll¤i§¥
h¦¢¥ ¢³£³¨¥¤³±ISERM³¢ ¢h¥²§±° §³«§¥²¢²
¦¢¤±§³¥¢«¢¤±§¨¢±¡¢±°¢³©¢¯§j¢©¢¥°±° §«§²§
³¢¥ ¥¤¢ ¯§ j¦¢°ª« ¦¢±° ² ¦ ³ ¢ ±² ¢ h¥
§¤j¦¢³§¦¢ ³³§h¦¢¯¯±° §³¢ ¦¢§ ³²¦²§¢³¢¢«
¦h³±¤²§¥«¢§dtla¤e¢¯°³±¦h©¢§³±¢²¥¤
j³¢³«§²§¥§
¨§¢§§°¥ ²³ª§²¢j¦¢¢¡±±° §³ª§§¤¦¦¢¥«³±¯
dInstitut Pasteure±¡ª¨¤§§¤h¥²§§§i¦¢²¢¥²¢©²i¦¥²
h³©©³©±°¢¢¥«¦¢©§§§³ª§²¢dInstitut Curiee¢±¢°¨¤§
dFRM iFoundation for Medical Researche¢±±° §¥ª§§¤
jd« ¯© ³²±¡ h¨¡±ªe ³§¢ª§ ³¥ § ±° ¦¢ §³§ ¦¢©¤§
±° §¥³¢§¥³©¤ªi³² ³¢©¤ª¢³²³±¯§°©± ¥
¥«¥¥¢ ³¥³ª©¥¢¤idAFRESe±° §³¤±«¥³©¤ªdANRe
j©²£±
©ª±¢¯°³
no
³¢¥£³±¯¦¢¥ ¢³¥²¦¯§^¢¤£¨¢¢¯¢©¢¥°±° §¥±²
¯§¥¦¢¥¤¢¦£¢j±«©§²«±°©§²§¦¢«¦¢²©j±©
¢¦¢¥«¨¥¢ ¢£±¢¤¦¢²¢±§©]{¢©¢¥°±° §³¤¢±«¥¨§
±° §¤±§©§°¨¤¥h^¢©¢¥°±° §³©¢¯§¥¦¢ ¢§¦¢¤±§±¯¢¥
jdCTRS dCenter for Translational Science Researchi¢§±³«§¥
mpoe±¢¨¢¥¢§mll£ª¢³¥²§§¨§¢§¥°©nlml³©²§²¦¢°§©
¥«¦¢²¢§¦¢¢¯§¢¢¦¢¤±§¥¤j¤±§¥¤¥h¦¢©²²§ ¥d±¥¨¢¥¢§
¤¢§³³¢§¯¨±°³¥°¥¦¦¢¯§©j¦¢¢§¥¨¢¦¢©°³¡¢§¢
¦¢± § ³±¢¯¢¥ ²§²¢ ¢³ª©¤² h±¢ ¨¢¥¢§ qll £ª ³¢³¥²§§
¦ ¢¥e ¦¢¢¥¢§¢ ¦¢¢©¢¥° ¦¢±° §¥ ¦¢¥¡§ ±° § ¢²§ ¥²
£³§±¢¥¢§nl¬ª¥j£±¢©¢²²¨§³ª§¨¤§jd¢¢²«³³±«§
±° §¥¦¢«¢§®¢±§³³¥³±ª§³±¯«¢¯²±¢±¢¥¢§ol
¥¤¤©¢¦¤³§d±¥±¢¥¢§nmjpe±¢±¢¥¢§mq§±³¢j¢§°
j¢±¢±° §¢«¥±©
¥« ¢h£°¡±±¨¤§¥©§±«²¥hd¢©§±ec³±°¡±©¢¢±c±
³©§§§³¡¢ª±¢©j¢©§±¢±¢±° §¥²¨§©§
h³¢©§±°¢¥±³³¢¤±§³©²³©¢§¥²§§¢¢¥«±°¢«
³¢ ¦¢¯§©²¦¢±° §§±¤¢©°¥ ¨¤¥h¦¢§¯§¯§¦¢¢¯°³¦¥
³h±³¢¥j¢©§±³¥³¢«§³¦¢²«©±° §
³¯¦³ª§¦¢©¤§sr§³¤±§hdMax Plancke°©¥ª°§
tna¤j¦¢ ±¦¢©«§¦¢±¡¦¢©«§rhpll¦¢«mohlll¥²¥¥¤
¦¢«¢§d±¥±¢¥¢§njpr¦²h±¢±¢¥¢§mjsn¥«§«e¢¯°³§
±©± ³ j³©¢§ ¨§¢§§ ¦³¢¯ § ¢¥± ¨§¢§§ ¦³¢¯ §
¦¢«¯³§³¥¢«§¦¢²¢¥²¢©²h¢§²¢¢±° §³°ª«dFraunhofere
mjq ¢¯°³ jd« ¢¢²«³ h¥²§§ ¥¢²e ©§ ¢¥
dHelmholtze®¥§¥¨±j¦¢«mshlll¦¢°ª«§h±¢±¢¥¢§
¥²¢¯°³§©©h²¢nrhqll¦¦¢°ª«§²±° §¢©¤§mq§¤±§
¢©²°±³¦«jd¢¥±¥²§§§¦¢«¢§¤³§ulae±¢±¢¥¢§njoq
¦d³°¢§³¥ §¥²¢¥¢±° ¥¨¡±ª±° ¥e¨±³ª§
j°§¦¢¢±¢¦¢
¦¢«muhlll¦¢°¢ª«§h¥²§±° §¢©°³§qo¦²¢³¢¥±¥²§§¥
RKmhPEmhBZgAe¦§§¤j±¢±¢¥¢§mjs£ª¢³©²¢¯°³§¦¢©©
¢±¢ ±° § ¨§¢§ ¦¢°¥ ³¢¡±¡ª v³¢§¥¨¢ ©ª§ ±¢¯°³
np
°ª§¢¥±±° §£©¢ ±²§j¢¥±³¢±±²§¥¦¢¤d«
£³§nla¤¦²h¦¢¢ ¢«§¦ ³¦¢±° §¥±¢¨¢¥¢§tqr¦
hdDFGe±° §¥³¢©§±¨±°j±²§°ª§²¦¢¡°¢±¥¨§¢§¥¥¤
±¢¥¢§mjun£ª¢³©²¢¯°³§³¢©©h¢²©¡©ª²³¢§¯«¨±°¢²
³©¢§³¥²§§¨§drlae³¢©§±³¢¥±¥²§§§«¢§h±¢
¦¢©§±¢¨¢¥¢§spl¤j©²¢§qa«oa¤¥hdplae³©²
shlll£³§mll£±«h¦¢± ³±°§¥«©¥¤j¦¢¢ ¢«§¢§ ³¥
³©¡°¨³¢±§j±¦¢¢ ¢«§³°§³§¢©§±³¢¡±³©±°
j©²±¢¨¢¥¢§ul§±³¢ª¢¢¨¡±ª±° ¥³¢©§±¨±°²¬
±¢¥¢§ple¢©§± ³¢±° §¥¨§¢§£ª£³§¦¢²¢¥²¢©²£±«
j¢¢²«³¦¢¥¯©§¢¢²«³§¦¢«¢§d±¢
³¢²¯«§¥²¢¥¥¤±¢¤§±«²¥hd¢²e¥©¡ª¥c±
¢§°§ ±¯³ ¥¥¤§ ojqa¤ «¢°²§ ¢² ¢¤ ¨¢¢¯ h¢± ±° §¥
£³§ jdpa§ ±³¢ ¢ «°² ¥±²¢e ³¢ ±° § ¥² ¢§¥
¦¢©§hd±¥±¢¥¢§ojpe±¢±¢¥¢§njp¦²hnqainla¦¤ª
±¢mll£±«h¦¤ª£³§«±¤³°ª§¥²§§j¢±¢±° §¥
±²³³°ª§¢¢²«³mla³°ª§³©±°j©²¥©¢§¦¥
¤¢±¯¥±²¢³¥²§§³¢¢³¢²«°²³§±¢¥h²¦²¥e
±jd©²¢§¢±¢±° §d±¥±¢¥¢§e±¢¨¢¥¢§sll¤«¢°²¥
±° §¥£©¢ ¥±²§¥²³¢³©²«±³¢©¤³¥©§¢³¥²§§¨§¢§
²©° ³°«dMOER iMinistry of Education and Researche
«¯³§±° §¥±«§¢³¥²§§¨§¢§§ula¤j³¢§¥°¢° °° ²
j¢³¥²§§¥¢©³¢©¤ª¥±° §³ª§¥¥³¡ª±¢©
¯«§ ³«¯§¨³±¢²¢¨ ¦¢°©«§ °ª§ ±° §¥ £©¢ ¥ ±²§
±¢¨¢¥¢§SRC iSwedish Research Counciledolle±° §¥³¢²
hd©²±¢¨¢¥¢§ule¢±±° §¥³¢²¯«§³³©§§§hd©²
¥«j¢§¥³¢§¯««¢¥«¦¢±° ¢¢¥«¡¥²©¥²¦¢¥©§± ²
³²²§ ¥±¥²ª«¢§¢±¢±° §¨§¢§¥¥¤§ula¤
¦³§¨§¢§§³¢¯ §¤¥°§¢©¢¥°±° §j¢²±¥±ª¢³
¢³±¢²³³¥©§h³¢ §³¯«§§³±³©³¢¯ §³h¦¢©° ²
¦¢¢ª¢©²¬³©± ¦¢©²²§ ±SRC¨§¢§j¢²³¢±
±³¢¦¢¢¥³¦¢²«©¦¢©«§h¥±²¢§¤h¢²jnla³ ¦¢¢©¢¥°
©ª±¢¯°³
nq
³¥§h³¢²³¤±«§¥j³¢©¯¢ «§³±¯°h³«¡°§¤¢§³±³¢
¥¥¢¤²² ¥©¡ª£h³©±³¢²¢h³¡¢ª±¢©¢¢¥«^¡§¥§^
¥¯¢©³±¢¥³±¡§²¢§±³±° §±³¢^¥«§¥§^³¢¡§±³§¢
±° §³¦«j¦ ³¨¢¢©«¥¦¢¥¥«¦¢°¢¡¢¥²§¢²«¢
¢¤h¢²¢¥¨³¯¢±¯³¢¢ «°²¨¤¢±¢
Losech Nexiumh Selokenh v¥ ¦¢±¯§ ³ ¥¯§ ³±¥ ±²²
±¢¥¢§mh±¥±¢¥¢§mjqh±¥±¢¥¢§ph±¥±¢¥¢§Pulmicort do
jd§³h±¥
¥±²¢§¦¢¯±§¢±
±^¢¦¢«§¥³¢¥±²¢³¢§¥¢§°¢²©³¢©ªh¨©±³±c±
³¦¢¯§§³h¤¥§«³¡¢²³±¢³¤¢²§h«
±§©e¢ª ±³¥²¢¤«¥²³¢¤±§³¯¥§²²
³¢§¥¨±°¦¢°¥³¢¢±³¢³¢³«§²§©²±¯¥§jdnllt
¨¢ ±¢ ³¢³± ³ ¢³² ¨§¢§ ³§± ¢±¢ ±° §¥ ³¢§¯«
§h²©¥±¥mo¤¦²e©²±¥¨¢¥¢§mll³ ¥i³¢§¥
jd¢²¨§¢§³§±¥
h«§¥³¢§¥¨±°±¦¢¢ ¢«§¥¦ ³²±h±¢¢¢©c±
«¢¯§«§¥³¢§¥¨±°¢¤ ¢dISF iIsrael Science Foundatione
²¢¤³©¢¯§ª¢ª¥«h¦¢±° ¢¢¥«²²³«¯¥¢³± ³¨§¢§
²¢¨±°¥j¦¢§ ³¥¤³¢§¢©³¢©¯¢ ¦¢³¢§«³±°¢¢¢¥«³«°©
¦¦¢¢±°¢«¢³±°§²h±¥¨¢¥¢§su¤¥«§«¥¥¤¢³©²¢¯°³
²¢¥²£±«j³¢¡±³©±°§¤§¨§¢§¨¤³^³£±h¢³¥²§§¯°³
©²±¥qlhlll¤¥²£ª¦¢°©«§¦¢¥°§¦¢² ¦¢²¢§¥¥¤§
¦¢¢°¢±§¦¢¡±©¡ª¥²£§©¦¤ªi¦¢©²²§ «¥²°³¥
¥²d¢±°¢«e¥¢±°¥ jd±¥ollhlll«±¥mllhllle¦¢¢±¢
³±¡§¥h³°¥ §³¢©¤³j¦¢«§¦¢§ ³¨¢¢³§©¢ISF³¢©¤³
¦¢¢ ¢«§ h¢¥©¤¡ ¦¢°¢§ ¦¢«§ v³ °¥ h¥ ³ ©
³¡© ³¢±¢ ³«¯ ¥« j ± ¢«§ ± ¢«§ h±
²npjpae±¦¢¢ ¢«§¦ ³³«¯¥¥¤§³ ¢¥¯¥
«¯¢¥¨§±ª §§¦¢¥ª²i¦¢¥ ¢³¥¦¢±²°¦¢±° hdnujra¥
jdoljsa¥²mujnae¦¢±° ¥¥¤§³ ¢¥¯¥¦¢¡©i±° §
¢±¢ ±° § ¨§¢§ ¦¢°¥ ³¢¡±¡ª v³¢§¥¨¢ ©ª§ ±¢¯°³
nr
±³¢¦¢¥h²±§¨¤§¢¢¥«¦¢©§§§h¦¢² ¦¢¢±¢¦¢°©«§
¦¢°©«§j³¢¡©³¥ §¢¯«¨¢©±°¢«¦¢°§³§d±¥mllhllle
§±¦¢±° ±ª§³¤²§©³¤¥¢±¢³¦¦¢² ¥
±¢£¥±ª§h§¥e©¡°¥±²¢³©¢§¦¢§ ³¢³³³¢±§
¢©¢¥°±° ¢°©«§jd·nlmlµquh·nlluµtuh·nlltµmolv³«¯¦°¥²
¨¦¢°¥ §hnlluinlls¦¢©²¦¢¤nq¥°¥ ²h²±§¨¤§¥²
jd¡°¢±¥¢²e±° ¥d±° §¨§³©°¥¢¤e¦¢¥ ³¢¨¢²
h±³¢§°§«²²¢²±§¨±°¥³± ³²¢§³¢¡±³©±°§¤
³¢§¥¨±°¨§¢§¦¢±° i¦¢±¥²¥¥¤±ª§³¥¥³§±³
³¯¢ ©³§¢²¢³ ¢¤§nllumlu¥nllq³©²qu§«§¥
³¢©¤³¨ISF¥²¥¢±³¢©¤³¨j±³¢ ±¬°¢¥¤¦¢©©©§¥²
¢©³ ³±²j¦¢ª©¢¤³©¢¯§¢¤±§h¢¯¦³©§§§²±§
¢¥«¢¢h³¢§¥«§±³¢³± ³±° §³¥¢°³©¢¢©«§¥±²¢¦¢¤
j¦³³¨§§¥
hdNCRDe ³¢¥±° §¥³¢§¥¯«§±^¢¥©²§h£¢¥±¥¢±§
¢§ ³¦¢¤±³§¥±²¢°¡¢¢¦ ³¨³«°²§ula²¨¢¢¯
³©§³«°²§dmlae¨¡°°¥ °±h³±²°³«¢§³¢¢¥©¤¡
³¢¥±²¢³± ²¤±³±³± nll§±³¢²¢¥«¬j¢¥©¤¡¢¥
¦ ³³¥«©¢¥¥³± §³ ¬h¨¥²¢¥©¤¡³³©¡°
³± sll£³§j¢±±²¤§¦ ³³± ±²«§® ¢¥©¤¡¢
h¢±±²¤§³°ª«orqd³©¡°³± ¨±²e¥±²¢¢¥©¤¡¢
¥ ^±²¤§^ ¦¢² h¥±²¢ ¥« ¦¢² ¨ ¢¥« ¦³ ¥¢ £¤
³¢±° §³¥§°ª§h¥±²¢± ª§¢¢²«³±²§j^³±³^
j^¢¥±¡¢©^hdmatchinge³§³
¥« ¢h¢°ª±ª¦²¥«¢¥³¢±¤±§¥©§h²±¢c±
³©¤ª¨^±° i±¥²³¢«³°¢ª«²± ¨¢¢©«
¢©² ³ §³¥ ¦¢¥«² ¨¢¤§ ¦¢±¢© ¦ ¦¢±° i¦¢± j^ ¤
³± ³¥±° §«¢°²¥¨§³¯§¥³ª©¥¦¢¤±§³«¯°§
³§«£³§¥²±° §³£±«¥¥¤¢²¢¤¦¥¦¢²±©¦¢²§¥«
ª¤© ¥« © ¥¥ ª¡¡ª ¥¥ h¦¢²§ ¥¥ ³ ¥¤ i ³³¢ ©
¦¢©§¡ ¦¢¢³¢ ¤©¥ ¢§° ¦¢³¢§«¥ ³©³¢© ¢¥¡°¥¡©¢
¦¢¥¤¢ ¦¢¡ ¦¢±° ¦² ¦¢¡ ¦¢± j³¢³±°¢ ³¢¡± °¢¡°±
j¢¢¡°¨£¤¥¦³«¥²¢h«§¥²§§¥²§±³¦±³¥
©ª±¢¯°³
ns
³¨¢
±©¢¢c±¨¢¢¯ª©¢¤¥²¢©²¦¢¦¢¢°³² ³¦¢©¢²§
£¢¥³³¡¥ ³¥°£¢¥³¢¤±§¢¤±§¢^¦¢± ¥³©«¢^¢¤
¦¢©³§§³¤±§® ¥³¯°±²¤¢¤ª±©°¢± ¥²² §±¢
±³¢¡³¢±¦¢°¢ª³±²°³³±¢¯³«³³ª¢¢§
±° §¥¦±¥¦¢¥¤¢¢³¥²§§¨§¢§¥²¦¢¥¦¢§¤ªh³§¢ª§³¥ §
¦¥²¨¯±±ª ¬¥«h¦¢¥±²¢¦¢±° ¥«j¦¢ª±¡©¢³§³¥²
³§°§³± ²£±¢±¢±° §³¦°¥§¥¥h¨¤³²«¥
¨³¢©£¢±¢¯±°³±¯¢¢§^³¥v¦¢² ¦¢¥°³°²§
¬j^¦¤¥²³«§¥¦³¨¢§¥¦¢°° §¦«±¥²¢j³«©¤²¥
c±¨¢¢¯h³±²°³²©³¯¦¢¢±²¦¢³¢«§²² «¢²¢¥«
¥«³¢¡±¡ª¢² ¦¢¢¡h«§¢²©h© ©±¢¥«^¢¤¦±©¢¢
³®§¥¥¤¢²±¢¯¢²©¢¢¥³¯§§² §²¢°¥£¢±¯jjj¢§
±¢§©¯§ ¤«^¢¤±§§¢¤ª¨©±c±j^§°¥²©
¢¢¤² ©¢d³¢¥±²¢e¢¢ª¥¤h¥¥¤¤j¥°³«³§¢³±³
±¢ª£c±j^² ¥«°¢±³£¤³±¥²¢j±° §§³«²§
±° §£§³¥d¥±²¢e¥²§§³«©¤²¥²°²³¥¥«³§^¢¢¤
^]§³¢±¥¢³¤¤¢§³¢¤¢¯¢³¢¡¢¥©¢ §j¢±
¥²^¨§³¤¥£±¯²¢^j³¢¡§¡©¢ ¥¯¢¤¨¢¢¯c³±°c±
³¢² ³²¢±©°c±j^³ªª¥^¦¢©³¢«¦¢°¢¡¢¥
¦¢± §¤ j^¢±¢ ±° § ¥² ¦¢¢¥¤¥¤ ³©±³¢ ¥« «¯^²
¦¢¥±²¢¦¢±° ²±±¯±²§±²¤¢¤±§±¢¦¢¥±²¢
h£§©£¤¥¤¢³¥²§§¨§¢§³¢³¤¢£¤¥¤³¢«§³±¯³°¢¥¦¢¥¤¢
³©¢§²¦¢² ¦^{«¦¤¥³³¥©¥§¥^v¦¢±§±¯¢¢°
¬ª¤³«¢°²©© ©w±° §°§³¢³±¯³¢±³¯±§¤³¥
«°²¥©¢¢±¢±° §¢¤¨¢¥¥¥«j¦¢± ³§°§
j©²±¥«§¨§² ³¢§¥
°§§±° §¨¢²¦¢³§¨¢³²¢©©²³± ² ¢ª
¦¢§«²¢¥«¬¢¤¨¢¢¯¥c±jd ³e¨¤§¥±° §¥d¬«³§e
±¢§³¢±° §³¦²¦¢©§²¢h³¦¢¦©¢¦¢©«§³±
³©§ª³hSARS ¥¢¡ §¥e ³¢ ±¤ ¢ ³¢± ¢«¥
¢±¢ ±° § ¨§¢§ ¦¢°¥ ³¢¡±¡ª v³¢§¥¨¢ ©ª§ ±¢¯°³
nt
¥² ¥¯³¤±«²¢²°¥«§«¥c±jd±§ ¢± ³¢³§¢²©
³«¯¥±²¢²¨¢¤§d³±«³¢¥²e¥¤³¢±«³
¦¢©¢¯§¦¢±° dª¢¢eHIV¬¢©¥²±°§³¦«j³±°¢¢ª¢©
¨¤§±° §j^§¢§«³²«©^±¥²ªh¦ ³¥¤²§©¦¢±
jd¦¢² £e¦¢ ©¦¢§ ³¦¢² ¦¢§ ³¢««¢¢ª¥¦¥¤¢
¢¥¥¤¨²e¨§§±° §§ ±¦±¡°ª¯¢¢§¨¤§±° §¬ª¥
±° § §¤ h ± ³¢« ¦ ³ ±° §¥ « d¯³ ¢³ § ¦¢«¢
¢¤j¦¢§¢ª§³¥£³¨¤§¥¨«¯³§±¢¥«²h¢§±³
j ³§¨¢h¨©±c±©¢¢¯²
¥e³±³¦¢¢©¢¥°¦¢¢ª¢©¥¥¤h¢©¢¥°±° §¢¢²¢¥²²©
¦¢¢¥¢§¢¦¢±° §d¦¢«©¤²§¢§³¥e±°§³ hd¦¢¢¥§¢§³
c±h¦ ³³±°ª£c±jd©¢§¥¦¢¢¢¯ª±¢¥«¦²e
¦¢¢©¢¥°¦¢±° ¦¢§³§¦§«²¦¢¢¤±§¦¢±³²¢²¥« ¢¨ª¢¥
³°¢ ²h³¢³²³h¨§¢§³©±°h³±¤²§h±° §¥¢©¨§¡«¢§e¥±²¢
¦¢«¯§¤¥«hd³¤© ¤±±ª §¦¢¥ ¢³±° §³±¢
¥¡©ªc±j¥¢«¥¦¢±³¦«§³¥¢¤¥±²¢«¯¥±²²
±¢³h³§³¢«¦«³§³§¢©¡¢±¢²¢¤©¢¢¯±©°c±
¢°§ ±¯¢¥ h¦¢¯¢±§³ ³ ±²¥ ³ª©§ ³©¢§ ¢³² ² ¨ ³
¥«¦¦ ¢c³±°c±¥c±j³¤© ¤±«¥³©¢¯§
j¦¢³©¢§§ ±¦¢¯§§
j¢©¢¥°±° §³¤¢³«¥¦°¥¦¢¤±§¤©¢¢¯¦¢¥±²¢¦¢±
±° §¥¦¢³¢§«³±°¢¥²³¤±«§¨©¢¤£±¯¥«§«¦±²¨¢
³§²³³²°d¢¡±¨¨§§§±±²e¦¢¥ ¢³«¯³§
±²¤³e¢«¯°§¦¢°³±°¥¦¢©¢¦¢§ª±³¤¢¥±³¢±¥
³¢³²³¨§¢§¦¢²±©£¤£±¯¥jd±¢¥«¢¦¢§ª±³§¤
²«©²±° §¥«c¤±©c²£¤«¢¥«¢¥ ¢¥¯©¥¦¥«¥^©²¨¢¤§
¦³¥¢«³±¢³ª¢±¤±§§¦¢±¢©²j^¦¢± ³§°§
³¢³¤§³³¢±° §³±³³¢ §¥©h³¢³²³²¢¢ ¢©¢²³
j¦°¥±¯¢¥³¥¤¢¦¢¥
¢±¢±° §¥±²¢£±«¥±²^¢¤¨©¢°c±¨¢¢¯¦¢±¦¤¢ª¥
¢¤ ¦¥ h^³± ³©¢§ ³§¢¢° §±§ ³ ©¢² §±
©ª±¢¯°³
nu
¥¥ § ¦¢§¥ ¦¢¢¯°³ ³¢³²³ ¦ £±¯ ¢¢ ³ ³²«¥
j³± ³©¢§¦¢§¢¢°
³±§¥¦¢¥±²¢¦¢³³²§¢¤©¢¢¯¦¢©¢³§¤¢ª¨©±c±
± °«¥ ©¢¥« ¢¢ j¥^ § ¦¢¤§ ¦¢ ± ¢¯² ³²§
±° §¦¢°£²§¥¢©¢ i©²©±^j¦¢³±«¦¢³¯¥§
j^¥±²¢¢±¢¢©¢¥°
¢¢³« ±¢¯°³
±° §¯§³¤±«¥
¥±²¢¢±¢
oo
±° §¯§³¤±«¥¢¢³« ±¢¯°³
¥±²¢¢±¢
nlluk¡^ª²³¢§°¦ª±²
§j
£¤¢¥h³¢©±§± ¥¤¥² ¥¯¦¢°ª¢¢±¢¯³¢±
«© ± j¦¥« ¦¢«§ ±° § ¢§ ³§ ¢±¢ ±° §
¦¢§± ³ ¨¢¥ ±² ¢¢ ¢±¢ ±° § ³±«² ±¤§
¥¢¡³±²§¢±¢±° §¨¤§¤j±§¨¥¯§¥³¥ §¥
³¢¡¯§±¢¢²«³¢¯§§¢¥«h±¢¯³¢±³¦°§h¢±
¦¢¢¯°³£§³©±° §±«§³¯±j³±³³ ³§³¢¥©¤¡¢
¦¢¤§³¦¢¢«¢¢¢«§¥©§³ª§³¦¢¥©§h¦¢¢³¥²§§
jd³±¯INSERMh¢¥©MRCh³¢±³¯±NIHv§¥e¥
¦¢²§³²±¥¦¢§«²¤ª§¨±¨¢¥±²¢¥³§«¥
j¦¢§¢³§
³± ³ª¢ª¥«¢±¢±° §³©§§§³©±°§¤²¢¥±²¢¦«
¢¢ ¢³¢±¢³¢³¥²§§¨±°j¦¢± ±° §¢§ ³¦«
³©±°§¤«j¦«¢¯°³£h³¢±±²§¥²¢²±¨«§¢¢²
±° §¥¦¢¥§¦¢¢¯°³¨¥h³§±³¢ª¤¥«±°¢«³ªª³§³¢«¢¢
j¨¡±ª§ ¥§¥¥²¨±°¨¤h¦¢¢ ¢¢¦¢¢±¦¢²©
³¥¤¢¢ h±° §¥ ³©¤«§ ³¢³²³ ±«¢ h±° § ¢°©«§ ¡«¢§ ¥²
¢°©«§¥³²°³²±°¢±¨§¥¡¢¦¢±¢«¯¦¢±° ¥²¡¢¥°
¢§«³±²§§±±° §¦¢¢°¥¦¢¥¤¢¦©¢¦¢±° h¦¢©¡°±° §
d¦¢¡¡¢¯³¢§¦e¥±«²¢²±©¨¤§¤j³¢§¥«³± ³
£¤¢¥j¦¢¥ ¢³¨¢¥±° §³¡¢ª±¢©¨¢¢©¢¥°±° §³§±
°¢ ®± ¢±¢ ±° § ¯§ ³ °¥ ¢§° ¡¢¥
³«³nllr±¡°nu¢§°¢²©©¢§£±¯¥h°¢§«§
³§¢²±±e¢§°¢²©³¢©ªh¨©±³±c±¥²³²±¢¢
jd ¬«¢±
³°¥³²°³§¢¢³«^v¢©¢§³¤ ª©²¢¤h«³±¡§
³¢©¢¥°±° §¥¥¤e¥±²¢¢±¢±° §¥²¦¢¢°¯§
¢±¢ ±° § ¨§¢§ ¦¢°¥ ³¢¡±¡ª v³¢§¥¨¢ ©ª§ ±¢¯°³
op
¢¯§§¥« ¥hd³¢¥©¤¡¢¢¢²«³¥¢±¢±° §¨¢°²§§
³ ¡¥§¢°¥ ¢¡¥¦¢¤±«¢¯¥h¨¤³²«¥¨¤©¥¯§³²¢§
³««°¦¢©¢£±¯¥j^ ¡²¢±° §¥¢¯©¡¥²¢±§¥¯¢©
±° §^vNIH¥²³±¥«³ªª§¢±¢±° §¥±¢¢
³¥h¨ ¥h«©§¥h¨¢¥³±¡§²² «¢²¤±¥²°§¢±¢
j^¦³¢±³¦°¥³¢¥§³¥ §±¥
¦² ¦¢§ ³ ³²¥²§ ¥¤ h ± h±© ¥¢¡ «
¢©¢¥°¢±¢±° §h¢ª¢ª¢±¢±° §i¥¡¥²°³
¦¢°¢²§¦¢§ ³²©£³§i¢¢²«³¥¢±¢±° §¨¢°²§§
j¥
«¢²§¥j³«²«±¤¥²²§² ¢§«§¢¢°¢¯ ©²¤
¨§³¢¯¥²°³©²h³¢§°¥©§¢²©¦¢±h¦¢±° ©§
§¤§«°±³±¢¢©¦¢±¢¤³¤¢±«j«¦¥¢¡²¦¢²©
«©§¦¢§ ³³²¥²§ ¥¤j¦¢©¢¥²±©²¥¤¤h¦¢§¤
²³°³«j¥^ §¦²¢«¢¦¢©«§«±²¥²¥²³°
³£¢±«¥¢¤¦¢©¢³²¢h¦¢±°¢¤±«¦¦¢§¢²¥²®±
j²©
²¢«¢©¢¨² ³°³«²¢²³
jdhh¦¢ ª©±e¢³¯¥§
«¢¯§§j
¨¢¯§§ ³±¥ « ¢©¢ ³ ¦¢§¤ª§ ¨¤ ¦¢§ ¦¢¯§§
j³¢©¯¢ ³°³«¥²¨¢³¯¥§
¢ª¢ª¢±¢±° §jm
±° § ¢ª ¥¤¥ ª¢ª h³¡¢ª±¢© ± ¥©³§ h ±° §
¢¯§§ ¢¥ j¢¥©¤¡¢ ±° § ¢©¢¥° ±° § ¥¥¤ ¢±¢
±¢ª±«¢²³¥¥¤ ³¢±° §«¢°²§¥±²¢³©¢§²¬h«
¥©³§¢ª¢ª±° §³± ³©¢§§³ ±«¢°²§¢h^¥³§
¢¯ §³ ¢¢ª¢ª±° §¥±²¢³©¢§¥²«°²j³¡¢ª±¢©
jdh¦¢ ª©eOECD³¯±©«°²§
¦¢²§ ±ª h¢ª¢ª ±° § ¦¢¥« ¦¢¢±°§ ³©¢«± ±² ± §
j¢§²¢¢¢©¢¥°±° §¥«¦«¢²§¤¢§³¥
¢¢³« ±¢¯°³
oq
¢¥«e¦¥«³¥¢§³©¢§±²«¨¢¢¥±²¢¦¢§¢ª§³«¯°§
±° §¢§ ³¥¤³¯§©¥±²¢¢©¢¥°±° §§¥jd¦¢¡¡¢¯ª°©¢
³²«©²«°²³¤³¥¤¦¥j¢§¥««¯§§¥«§¢±¢
¦¥«¦¢³¢§«¦«³± ³¥¦¢²°³§¦¢¥±²¢¦¢±° ¦¢¤j±«
±° §³¯°hd³¡¢ª±¢©e³©²¢§±° §³¢³²³h¢¯°³±ª ¥²
¥¥¤£±¦¢¤±«¦²h¦¢¡©±¡°±³±ª ±«§¥°§§³©¡°
¢±° §¦¢±° j¦¥«¦¢¡±° §¢¤±§¢ª¢ª±° §³
¢³¢²³±¢¯¢¦¢²§ª¢±¨§¦¢«¢°²§¥±²¢¢ª¢ª¢±
j¦¢±° §³¦°¥¦¥±²¥¢¤®±¥® ¦¢±° ¦«¥«
¦¥h¢ª¢ª¢±¢¦ ³±° §¥²§¡¥¢¯©¡®±²¢
±³¥¢¤j³±¢¯¢±²¤¥§£¤¢¥¢¥¯©§©¢¦¢§¢¢°¦¢©³
h§¢³§ ¥© ³¥« ³¢«¢¢ ¨±° ¦¢°¥ ¯¢¥§§ « ¥ ³¢«
¦¢¢°¢«§¥¢¯©¡¥¯©¢£¤j¥i¢±¢±° §£§³³²
j¥§¥±²¢³©¢§
¢©¢¥°¢±¢±° §jn
¦¢¥ ¥¢¡³§±¥«±¢²¢«²§±¢©¢¥°±° §¥
¨§§§©¢²¢©¢¥°±° §j³±³¥²¨ ³¢£¢¥³² £©¦
³¦¢¤±«¥¥¤£±j¦¢¥ ¢³±²«©³±³³± ¥²¨ª¤§
¢©¢¥°±§ ¦¢©¥²¢¢±¢¤±h³¥ §³±¢²¢°ª«h¦¢±
jd ¬³°¢§³±±e¦¢¥ ±°§²
³±³ ¦¢± dclinical trialse ¦¢¢©¢¥° ¦¢¢ª¢© ¦¢¤±«© ¦¢¥ ¢³
¦¢ ¢±§¦¢¥ ¢³j¨¢§§¨©¤³¢¥¦¢«¯§¦h³¢²«³¨§¢§
¦ ¤²¢²¢«§³¥¢«j¤±¥°³§±h¥¦¢±° §§±¬ª¤
j£¤¥¨§¢§¯§¢¢¦¢±°§±° §¦¢¢°¥¦¢±¥²
³¢±° §³¥¢«¤¢§³¦¢±²§¦©¢¦¢±¥²°ª«¢©³¦
¬¨¢j³¥¢«¤¢§³¥²³¢³¤¥§§³¢©¢§¥¥¤¨¢h²«§¥j§¢
¢©¢¥°±° §¥²§¢°j±° §¢©¢¤«¢¯§³¢©¢§«°²¢³¤¥§§
¦¢¥ ¢³²¦¢¢³¦¢¥ ¢³¢¥©§¢¥«°±£«°©§¢°¢
®± ¦¢¤ ¨¢ ³¢± ±²§ ¢²± ¨«§ ³¤²¥§ ¥ j¦³¥«
¦¢©³±«¢¨§¢§¢¢²°¥«¬ª©j±¤¢©¬°¢¢©¢¥°±° §¨§§§²¬
£±«¥¦¢¯±¦¢±¥²¦¤±¦¢§«id¢©¨§±ª §¤e¦¢§¢³§
¦¢±¥dmentorse¦¢¤© ¦¢±ª ¦²«§²«i¢©¢¥°±° §
h¦¢¡«§ h¦¢± ²¢ ¨¤ ¢ ¥« ¬ j±° § ¥¢ ³¥ ¦¢²°§ ¦¢±¢«¯
¢±¢ ±° § ¨§¢§ ¦¢°¥ ³¢¡±¡ª v³¢§¥¨¢ ©ª§ ±¢¯°³
or
±²¦¢¥ ¢³²¢h¢©¢¥°±° §¦ ³¨¢¯§±° §¦¢¢°¥¦¢ ¢¥¯§
j¦¢©¢¢¡¯§¦¢©¢¥°±° §¥¢¢¯°³ª¢ª¦§¯«¥±¯¢
«°¥¥¤¢²³¢¤±§³²±¨¢³±§¦¢¥ ¢³¥«³¥«²± §
³¢±¢¨±°³±ª§¢ ¢¦¢°¥«¢¯§«h¢ ±° §³¢©¢§
j§¢°¥¥±²¢¢©¢¥°±° §¨§¢§¥³¢± §¯«±³²h²
¥« ªª§ ¢¢ ² ³¢±¢ ¨±° ¢ª¤§ ¢ ³¥¢« ¨§¢§
j±° ±¥²±¢¢±°¥²¦¢©²³ ³³¢¥²±° §¢°©«§³¥§
j©¢§¢©¢¥°±° §£±«§ª¢§¥¢¢«¯²°§«
¢¢²«³¥¢±¢±° §¨¢°²©§jo
¥¯©¥±²²«¢¥¢±±° §£±«§±¯©²«¢¥²³¤¢£¢¥³
® §°¥ «¯³§±¬ª¤³«°²²±¢¥²±£¢¥³³¢¥¤¥¤
j³¢¡¢ª±¢©³±ª§¥
¦ j¦¥« ³¢¥©¤¡¢ ¢¢²«³ ¬°¢ ±¤¢© ¥¢ ¥ nlln ³©²§
¨¢¢« ¦¥ h ¦ ³ ³°ª« °© ³± ¥² ¨±ª§ ¥ ¥±²¢
±ª ¯«©¢ªh«³«¥j¦²¢¢¥³¢±³¢¥©¤¡³±ª
¢¥³¤ ¨¢ ¢§²¢¢ ¥¢¯©¡ ¥« ¢±¢ ±° § «¯¢¥ ¦¢²§
¢ª¢ª«¢³±«¥«©§§£±«§¢¤¯§«j³¡¢ª±¢©
³±«¥³± ¥«¨ªª§h¢§¥ ³§®±³¡¢ª±¢©
±²§ ¥² ¢²± ¨«§ ³¢©¤³ ¥« ¨ ³¡¢ª±¢© ¥² ¢¥©¤¡
³° ¥² ¨ ¦¢¢¡± ¨ h¦¢¥ ¢³ ³¡¢ª±¢© ¥¤¥ j³^§³
j¦¢³ª§ ³¥³§² ³¢¥³ ¥« ¦¢¡©¡ ¦²¢±¥ ³±ª§ ²¢ h¦¢¥
j©¢§¢«¢¯§²¦¢¡©¡¦²±¥¦¢¤±¦¢¢³¥²§§¦¢¥ ¢³¥
¦«¨§¦¢©³©¦¢²©¦¢¥¦¢¥ ¢³³¥©³¢±±²§
±¢¥¢²¦¢¡©¡¥²¦²¢±±¯¢¢¢¥©³±ª¥«¢¥¥¤²
³ª§¦¢¢³¥²§§¥¦¢¥ ¢³¦¢¥°§¦¢©³¥¦¢¦¢©³
¦¢¥ ¢³§d«§²§¢³±³e¢²©¨³ ¢±«©§¥¢¤j®±¢§°
¢³¨¢³¥¥¢¥²©³±ª¥¢¥¯¢¥§§«¦¢¢³¥²§§
j¥±²¢±° §³ª§±²¥¦¢¢³¥²§§¦¢¥
¢¢²«³ ³¢³¢³¥²§§¤¢§³¥³¢«¨³¢³²«¢¥±²¢³¥²§§
¢± ¢±¥ j³¡¢ª±¢© ¢¢¯°³ ¯¯¢° £ h³¢¥©¤¡¢
³¢ ¢¥¯² ©¢§ ¥« ¦¥ «¢ ¥^ h³¢©¯¢ ³° «
³¥¢« ¦¢¢¯°³ ³¯¯°§ ¢ ³¢©§ ±²¤ h³¢¥©¤¡¢ ¢¢²«³
j^¢¢²«³¥ª¢³§³¢«§
¢¢³« ±¢¯°³
os
j^³©¤³¢¨ §^³¢§²¢¢±¡§¥¢ª¢ª«¢¦²¢¢£¢¥³¢¡¢±°¥²
³¥¢ª¢ª«¢³¦²¢¢¥±²¨¤² ¢¤§¨ §¥²³ ¥¯
¦©¢¨¢¢«¢ª¢ª±° §¥²³±«²¦¢±° §¥¨§¢§j±¯§©§§
±° §³¦¢©§§§²¦¢§¥¥¥¤¢©¢¢³¢¢²«³±° §¥¦¢¥²
j¢§²¢¢±° §³¦¢©§§§²¦¢§¥¢ª¢ª
¢§° °²§§ ¤¢§³ ¢¥¥ª§ §¤ ³^§³ ±²§ ¥² ¢²± ¨«§¥
³ª©³±ª§£¢±¯²«°³¢©¯¢ °¢³«j¢¦¨¢£h¢¢²«³
j³§¢ª§³¢ª©©¢³±ª§£¤£±¯¥«¢¯h³¢ ¢¢³¥¢«¨§§³²
±¢«¥¡¥ ¨¤¥h«¢± ¥²³ §³¦ ³¥® §¨¢¢©«
jd³^§³¢²±¨«§¥^§¥§¥¥²§¥e¦¢§¢³§¦¢¥¯¥§
±° § ¢± ¦ ³±³ ¥² ¥¯§ ³¢ ¢§²¢¢ ±° § ¥² ³ ¥¯
¡¢ ¨©¤³¥ ¦¢«¢ ¦¢± ¦¢¥©§² ¡ ¢©¢¥° ±° § ¢³¤¢ ¢ª¢ª
j£ª§¢©¢¥°±° §
³¥¥¤¢©¢¥°¢±¢±° §£±«§ ¢¡²±ª«£¤¢¥
j±¡§¦¦°¢
³¯¥§j
¢±¢±° §¥³¢§¥¨±°³§°vm¯¥§
³¢§¯«¢³¢±¢±° §£§³³²¨±°¦¢°¥¯¢¥§§« j
¢©¢¥°±° §¨¢ª¢ª±° §¨£§³³¨±°j³± ³©±°§³±©
translationale¢§±³±° §¦¢±° ¦¢±¤¢§³²¦¢²³
j³¢±¢¢¢²«³³«¢²dresearch
¢§° ¥« ¨±° ³§°¥ ³¢± ³ ¥¢¡¥ ¯¢¥§§ « j
¦« «§¥ ³¢§¥ ¨±° ¦« ¦¢³ h¦¢«§¥ ³¢¥±²¢ ³¢§¥
j³¢±±²§
³§±³¢²¥ ¢¥¯«§¥³¢§¥¨±°²°¢ª«§²« j
³¢©¢©³¥ §e¢±¢±° §¦ ³¦¢ ¢§¦¢²©¦¢°¥
«j±±¯±²§¥²dmatchinge³¤¢§³³¬d³¢¡©
h¥¦¢°©«§¥¢©¥³±©³±ª§¦¢°³«§¥³¢§¥¨±°²¯¢¥§§
j³«¯§³¢±¢¨±°¥²¨¢«±¢³«³¢¥¢²«¢
²±©¬°¢¦¢²§ª¢£¢¥³³§°³¦«²¯¢¥§§« j
£³ d±³¢ ¥¤¥ ¦¢©² ²§ £³ ¦¢¢³ª¢ £¢¥³² °³ £³§e
¢±¢ ±° § ¨§¢§ ¦¢°¥ ³¢¡±¡ª v³¢§¥¨¢ ©ª§ ±¢¯°³
ot
j³¢§¯«³¢³¤¥§§¨±°¥³¢±¢¨±°
j©²¥±¥¨¢¥¢§mll¤®¥§§¨±°³¥¢«¬°¢ j
±¢¦ ³¢ª¢ª±° §¥¨§¢§³ª³vn¯¥§
¦¦¢¢©¢¥°¦¢¡¢¥¦³¢±° §³¢³²³¢ª¢ª±° §²± §
¢ª¢ª±° §¤¢§³³±³¥¯¢¥§§«h¢¥©¤¡¢ ³¢¥
¢ ¨±° °¢©«³ ¤¢§³ ³ j¦¢²§ ³ª³ ³«¯§ ±¢
jm¯¥§³«¯§h² ³¢±
¦¢¤±§ ³§¯« ¢©¢¥° ¢±¢ ±° § ³¢ vo ¯¥§
¦¢±° ¦¢±¥²¦ ¢¡h¦¢¢±
¯¢¥§§ « ¦¢¢± ¦¢¤±§ ¢±¢ ±° § ¢« ¦²¥ j
¢ ¢¢²©¤±³±²² ³¢±¢¨±°³¢§¯«¢ ¢¦¢°¥
j
±° §³¦¢¯«¥¢¢¢±¢±° §¥¢ ¢¥²¢±°¢««¢ j
h¦¢±¥¤§¦¢°ª«³ ¡¥³§¤³¤¢¦¢¢±¦¢¤±§
j±° §¢°©«§³¥§³¤±«§³±«h±³¢¦¢±¢¤¥«¦¢¡©¡ª§
¢ ¢ ³¥¢« °§³³ ³©²± ¦¢©² ²¥²² ¯¢¥§§ « j
±² h¦¢§¢¢° ¦¢¢¡¢ª±¢© ¦¢¢± ¦¢¤±§ ³²² ±°¢«
h¨¢±h¢²hªe±° §¥³¢³²³ ³¢±° §³©¢¯§ ¢¤
¢ ¢¦¢³¦¢©²²¥²¦³jd¦^§±h°±ªh·¥¢¤¢µ¢¥³
©³£¤h±¢²¦¢©¢±¡¢±°£§ª¥« ¢±¤±§«¬±¢¯¥±¤§
j¨¤§± ¥¦¢©²²¥²¦
¢§±° §³©¢¯§¢¤±§¦¢°¥±²¢¢¦¢± ¦¢¢±¦¢¤±§ j
j¨±°³§°¦«
³¥« j ¥ ª© ³©³¢© ¦¢°©«§ ³¥§ £±«§¥ ³¡±§ «¯ j
j©²¥¦¢¥°²¨¢¥¢§ql¤v£¥¢³¢²¢§ ©²§h«¯
¢¢³« ±¢¯°³
ou
¢§²¢¢ ³¢¢¤±¯¥«¢§¢¡¢ª±¢©±° §¤¢§³vp¯¥§
¢¥©¤¡¢±¢¢§ ³
³©¢¢©«§²³¡¢ª±¢©¨³¥¦¢¯¢±§³³³¥¯¢¥§§¢¢³« j
j±° §¥²¡¢¨¢¥³¤¨¢ ³¥
¥« ±° § ³¥¤¢ ³ ±²¥ ³¥ ¥«³ ³«¯§ ¨±°² ®¥§§ j
j¦¢¢±¦¢¤±§¢§°¢§²¢¢¥¢¯©¡
³§ §±¯§¥«¢³¤¢¥²¦¢§°³§¦¢¥²£§³¥¥¤³¥¨±° j
j±©±°§§¥¨§¢§¥«j¦³¥«
±° §²©³¢©¯¢ «¥²¢³«¯³¨ ¥¯¢¥§§« j
³¯ ¦¢¢±³©¥¢ ¦¢¢³¥²§§ ¦¢²§ ¦¢ ©¢¢ h¢§±³
j³¢«¢¢ ³±¢
±° §¦ ³¦¢² ±° §¢©¢¤ ³¢¥¨©©§³§°vq¯¥§
¢±¢
¨©©§¦¢°¥¢¥«¥°¥²°³³¦¢«§¥³¢¥±²¢³¢§¥¢§°
h¦¥«³¢ ³³³§«¥¥±²¢³¢±° §³¥¢«³°¢¥«°
±ej¢§°«°³²¢¤h£±¯¢¥«¦¢¢©² ±° §¢©¢¤ ³¢¥
dj ª©
¦²¢±¢© ±¨¢¢©°¥«¦¢±° ³¢¤¥²ª¢§±ªvr¯¥§
¦¢¢³¥²§§¦¢¢±¦¢¤±§¦¢¡©¡
¥²e ¦¢±° ¥² ¦¢³¢¤ ²© ³ ±¢ª¥ ¯¢¥§§ « j
¦¢¥ ¢³«±¥¥¢¥²£±¢© ±¨¢¢©°¥«d¦¢¥ ¢³
¤±ªj¥±²¢¦¢±° ±²³§«¥¦¦¢±° ¦¢¢³¥²§§
¢ª¢ª±° §¢¯§§¥²¢¥¤¥¤¦²¢¢¥¢¥¦¢±° ³«¢
j¤±«²
¢ª¢ª¥§³¦¢¢³¥²§§¦¢¥ ¢³®§¥¯¢¥§§« j
±¤§ ©² ¢¤ ª§¥ ±° ¥ ¢© ± ¨¢¢©° ³ ¡ ¥² ¢¯±
° ¥«ªª§¥§j¥±²¢³©¢§¦¢¢§°±° §³ª§
j§¢«±³¥²h³¢±³¯±dBayhiDolee¥¢¢